SPONGEBOB SquarePants creator Stephen Hillenburg died aged 57, Nickelodeon confirmed.
Hillenburg announced in March 2017 that he was diagnosed with motor neuron disease.
In a statement, the children's television network said: "We are sad to share the news about the passage of Stephen Hillenburg, the creator Spongebob Square Pants.
"Today we notice a moment of silence to honor life and work."
Former marine biology professor Stephen worked SpongeBob from 1999.
In a longer statement, the broadcaster added: "Steve impressed SpongeBob SquarePants with a unique sense of humor and innocence that brought joy to generations of children and families everywhere."
"His original characters and the world of the Bikini's ass will long be a reminder of the value of optimism, friendship, and the limitless power of imagination."
Besides creating the character, Hillenburg also directed 2004 SpongeBob SquarePants Movie.
He survived his wife, Karen, and his son, Clay.