Thursday , August 11 2022

The discovery of a serious link between appendix and Parkinson's disease: an important step forward


Parkinson's disease is affected by the annex. It is the summary and hypotheses supported by neurologists around the world who have initiated a broad study of nearly 1.7 million patients. Published in the journal Science Translation Medicine, the study shows that patients who had an appendix removed had up to 25% less chance of being unaffected by Parkinson's disease.

Obvious links

Parkinson's disease, named after James Parkinson and described in 1817, is the second most common neurodegenerative disorder after Alzheimer's disease. Also known as an aging disease, it begins around the age of 45 and can be reported over the next 30 years. It is a chronic neurodegenerative degenerative disease, that is a progressive brain loss that results in a deficiency of dopamine in certain brain structures. This affects the central nervous system (responsible for progressive disorders: slow movements, tremor, stiffness and cognitive impairment). Its causes remain little known, although there is substantial evidence that the intestine is partly responsible for it.

Indeed, today we know that Parkinson's disease develops in the gut using the nerves to return to the brain. One fact is not surprising, because one of the first symptoms of the disease is constipation. The researchers also noticed that a protein, alpha-synuclein (a protein that is precisely associated with the disease), was in the form of abnormal agglomerations in the gastrointestinal tract. Viviane Labrie, lead author of the study, explains that " although its reputation (appendix) is largely "useless," the appendix actually plays a major role in our immune system in regulating the intestinal bacteria composition and now shows us our work at the beginning of Parkinson's disease". Let's understand here that the alpha-synuclein protein accumulates in the intestine after an immune reaction to toxins and bacteria.

However, this is a difficult explanation to maintain as the primary cause of Parkinson's disease. As a slow-acting disease, it takes years to discover that dopamine cells degrade to such an extent that the body experiences tremor or muscle rigidity. However, the researchers believe that brain cell damage is linked to how alpha-synuclein curves and aglomerates in some people. In addition, it can be noticed that over the decades, the accumulation of this protein is increasingly important, resulting in alarming interactions between the brain and the intestine. Solid evidence certainly, but there is, however, the fact that the slow progression of the disease is preferable to people who are at risk. This makes it difficult to get and interpret the results of studies for people who do not pose risks at first.

© youtube / FUTUREMAG – ARTE

Towards a better understanding of the causes?

Recently, it is a study by neurologists around the world that has asserted two hypotheses about the probable causes of Parkinson's disease. For this, they have linked the details PPMI (Initiatives of Parkinson's markers); is a clinical observational study that collectively evaluates important cohorts of interest using advanced imaging, biological sampling techniques and clinical and behavioral assessments to identify biomarkers of Parkinson's disease progression. And the records of the Swedish National Registry of Patients for the purpose of looking for possible links between neurodegenerative disease and apendectomy.

The vast study, which focused on the follow-up of nearly 1.7 million people, shows a difference of nearly 20% less likely to be predisposed to Parkinson's disease between non-addictive and intact appendages. Even better, the researchers pushed the comparison even to the housing places of patients between urban and rural areas and they noticed that the difference went up to 25% less fortunate for those who did not have an Annex.

The study does not show in any way that removal of the annex will immune you to this disease, but adds new insights to Parkinson's causes. fit Vanessa Fleury, neurologist at Geneva University Hospitals "This research supports two hypotheses: Parkinson's disease begins at the beginning of the digestive tract and environmental factors such as exposure to pesticides play a role in the development of pathology in genetically predisposed individuals."

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