Women working near crowded roads are at high risk of developing breast cancer due to traffic-based air pollution, researchers have warned. The team at Stirling University in Scotland analyzed the case of a woman who developed breast cancer after spending 20 years working as a border guard at the busiest North American trade border. The woman was one of at least five border policemen who developed breast cancer within 30 months of each other and, at another crossing, cases were observed. According to Michael Gilbertson, the findings "infer a causal relationship" between breast cancer and very high exposure to traffic-related air pollution involving mammalian carcinogens. Also, a link between night work and cancer has been identified. "This new research shows the role of traffic-related air pollution, contributing to an increase in breast cancer incidence in the general population," Gilbertson said. thought to have been caused by exhaust fumes as researchers have marked a "new occupational disease."
There is a probability of 1 in 10,000 cases as a coincidence, the study published in New Solutions magazine said, because the cancers were so similar and close together. An analysis of previous research has confirmed that BRCA1 and BRCA2 genes – which try to stop tumors – can be "silent" by exposure to dioxins and polycyclic aromatic hydrocarbons – both found in exhaust gases.BRCA2 is rapidly degraded in the presence of aldehydes – and components of exhaust fumes. "There is much more research to be done," Gilbertson said. "But now we have plausible mechanisms to infer how BRCA1 / 2 tumor suppressor in this highly exposed frontier fence has become dysfunctional and probably contributed to the ongoing epidemic sporadically, early onset, premenopausal breast cancer among her colleagues, industry and government can plan new projects for industrial and commercial installations to reduce occupational exposure to traffic-based air pollution, "Gilbertson said.