Thursday , April 15 2021

Repeated abortion reaction linked to a poor hope



sperm

The study at the beginning of the study, conducted by researchers at Imperial College London, investigated the sperm quality of 50 men whose partners suffered three or more consecutive interruptions.

The research, published in the journal Clinical chemistry, showed that compared with men whose partners had no loss of weight, the sperm of those involved in the study had a higher level of DNA damage.

The study team hopes that these findings could open new ways to find treatments to reduce the risk of spontaneous abortion.

Loss of recurrent pregnancy affects about one in 50 couples in the UK and is defined as the consecutive loss of three more pregnancies before 20 weeks of gestation.

Until recently, it was thought that spontaneous abortion was caused by maternal health problems such as infection or immune problems.

However, doctors now realize that sperm health can play a role, "said Dr. Channa Jayasena, lead author of the Imperial Department of Medicine research." Traditional doctors have focused on women when looking for the causes of recurrent miscarriages. the health and health of their sperm was not analyzed.

However, previous research suggests that semen plays an important role in the formation of placenta, which is crucial for the supply of oxygen and nutrients to the fetus. "

In the new research, the team analyzed the sperm of 50 people who were patients at the Recurrent Motion Clinic at St Mary's Hospital in London, part of the Imperial College Healthcare NHS Trust.

They then compared the results with the health sperm of 60 male volunteers whose partners did not suffer spontaneous miscarriage.

The analysis showed that sperm from men with spontaneously aborted partners had twice as many DNA damage compared to the control group.

The research team suggests that this damage to DNA can be triggered by so-called reactive oxygen species.

There are molecules formed by seminal material (the sperm cells containing sperm cells) to protect sperm from bacteria and infections. However, in sufficiently large concentrations, molecules can cause significant damage to sperm cells.

The results of the study showed that sperm from men whose partners had spontaneous abortion had a fourfold increase in the amount of reactive oxygen species compared to the control group.

The research team now investigates what can trigger a high level of these reactive oxygen species.

Dr. Jayasena explained: "Although none of the men in the study had any ongoing infection, such as chlamydia – which we know can affect sperm health – there may be other bacteria from previous infections that persist in the prostate gland, "Which can lead to a constant high level of reactive oxygen species."

He added that there is increasing evidence that obesity can reduce sperm health – possibly because high levels of fat in the body can trigger an increase in reactive oxygen species. Therefore, the team analyzes the metabolic health status of the 50 men in the study and assesses the levels of weight and cholesterol.

Men whose partners suffered miscarriage were also slightly older than the control group – with an average of 37 years versus 30 and a little overweight. The team is now investigating whether these factors can affect the levels of reactive oxygen species.

Dr. Jayasena concluded: "Although this is a small study, they give us clues to follow. If we continue to confirm that high levels of reactive oxygen species in the semen increase the risk of spontaneous abortion, we could try to develop treatments that reducing their levels and increasing the chance of a healthy pregnancy.

"The drug lasted a long time to realize that sperm health plays a role in spontaneous abortion – and that the cause is not just for women. Now we realize that both partners contribute to repeated abortion, we hope to get a clearer picture of the problem and start looking for ways to ensure more tasks lead to a healthy baby.


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