Thursday , June 8 2023

Klinefelter: is the disorder that affects the genitals and male fertility


Klinefelter syndrome or XXY syndrome is one of the most common genetic disorders in men: it occurs at 1 to 576, according to a study conducted in Denmark at the beginning of the 90's by the Aarhus Psychiatric Hospital.

People have 23 pairs of chromosomes, and the last one determines our sex. For women, it is composed of two identical chromosomes (XX) and, in the case of men, two different chromosomes (XY).

Genital and male fertility are genetically affected by Klinefelter's disorder.

Men with this syndrome have at least one more X, which in most cases leads to karyotype 47, XXY or, in rare cases, karyotypes such as 48, XXXY or 49, XXXXY. Therefore, Klinefelter's syndrome is also called XXY syndrome.

Klinefelter's syndrome is also called XXY syndrome.

One of the main consequences is the deficiency in testosterone production, male sex hormone. The body of people does not naturally generate it, so many people are injected each month since it detects the syndrome.

For many men with Klinefelter, though not all, genitalia does not fully develop and remain smaller, which prevents the production of testosterone.

One of the main consequences is the deficiency in testosterone production.

As a result, breasts may increase more than normal and puberty may be delayed or not even occurring.

Given low hormone production, fertility is impaired. If the syndrome is detected early, sterility can also be stopped.


In addition, they are at a higher risk of developing Type 2 diabetes, blood clots, involuntary tremor, breast cancer, osteoporosis, rheumatoid arthritis and lupus, according to the National Medicine Library of the United States.

"The problem is that many people are not diagnosed," he says. It is so little known that even some of those who suffer do not understand at all"Says Diego Yeste, head of the pediatric endocrinology unit at the Vall d 'Hebron Hospital in Barcelona.

At the moment, Spain's Klinefelter syndrome is more and more diagnosed due to amniocentesis, a pregnancy test.

It can be detected.

Extract a sample of amniotic fluid that is analyzed to detect genetic changes like this. Faced with a serious abnormality in the fetus, the mother may ask for an abortion in the first 22 weeks.

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