Mannose sugar could improve cancer treatment

Spanish >> Science-Technology

Updated on 11/23/2018 – 10:44

Keywords:cancer, treatment, sugar, mannose, improvement

Cancer cells – Archive

London, 23.11.2018 (The People Online) – Some natural supplements, such as mango sugar, can be of great help in the treatment of cancer. According to a study funded by Cancer Research UK and Worldwide Cancer Research and published today in Nature, this nutritional supplement does not appear to only delay tumor growth but also to improve the effects of chemotherapy in multiple-type mice. of cancer, stresses ABC.

It is known that tumors use more glucose than normal and healthy tissues. However, it is very difficult to control the amount of glucose in your body with just the diet. In this study, the researchers found that mannose can interfere with glucose to reduce the amount of sugar cancers that can be used.

Professor Kevin Ryan, lead author of the Beatson Cancer Research Institute in the UK, says: "Tumors need a large amount of glucose to increase, limiting how much they can use, they should slow cancer progression. that normal tissues need glucose, so we can not completely eliminate the body.In our study, we found a dose of mannose that could block enough glucose to delay tumor growth in mice but not so much that normal tissues were affected "This is an initial investigation, but it is hoped that finding this perfect balance means that in the future mannose could be given to cancer patients to improve chemotherapy without harming their overall health.

Tumors need a large amount of glucose to increase, thus limiting how much they can use, they should slow cancer progression.

In their study, the researchers first examined how the mice responded with pancreatic, lung or skin cancer when mannose was added to drinking water and was given as an oral treatment. And they noticed that addition of the supplement significantly reduced tumor growth and did not cause any side effects.

To test how mannose could affect cancer treatment, mice were treated with cisplatin and doxorubicin, two of the drugs most commonly used in chemotherapy. They have seen that mannose has improved the effects of chemotherapy, lowering tumor growth, diminishing tumor size, and even increasing the life of mice.

Other types of cancer, such as leukemia, osteosarcoma, ovarian cancer and intestine, have also been investigated. The researchers cultivated the cancer cells in the lab and then treated them with the mannose to see if their growth was affected.

Some cells responded well to treatment, while others did not respond. It was also found that the presence of an enzyme that decomposes mannose into cells was a good indicator of the effectiveness of the treatment.

Mannosa is sometimes used for short periods of time to treat urinary tract infections, but its long-term effects have not been investigated. It is important to do more research before mannose can be used in cancer patients.

In this regard, Martin Ledwick of Cancer Research UK, believes that although these results are very promising for the future of cancer treatments, this is a very early investigation and has not yet been tested in humans. Patients should not prescribe mango because there is a real risk of negative side effects that have not yet been tested. It is important to consult with a physician before you change your diet drastically or take new supplements ».