The researchers developed a calculation model for five types of infections based on data from the European Surveillance Surveillance Network (EARS).
For 2015, they calculated the number of people infected at 671,689 and the number of deaths attributable to multi-drug-resistant bacteria at 33,110.
The impact is "comparable to the cumulative effect of influenza, tuberculosis and AIDS virus" over the same period, according to the authors.
Most deaths affect children under the age of 12 and over 65.
The impact on mortality is higher in Italy and Greece (the first of these accounts for more than one-third of deaths), according to the study.
The medical sector is constantly warning about the danger of excessive or inadequate use of antibiotics, which makes bacteria resistant to these.
An Australian team outlined in September the dangerous spread of bacteria resistant to all existing Staphylococcus epidermidis, which can cause serious and even death, and is linked to methicillin-resistant Staphylococcus aureus (MRSA).
Of the 671,689 infections caused by a multi-resistance bacterium in 2015, about two-thirds were contracted in the hospital.
Researchers urgently emphasize antibiotic resistance as a vital health fact and the need to develop alternative treatments for patients with other diseases and who are more vulnerable because of their immune defenses or age.