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A sweet cranberry substance can help fight cancer cells



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BBC



Posted in:
Thursday 22 November 2018 – 1:29 PM
| Last update:
Thursday 22 November 2018 – 1:29 PM

Researchers have been able to slow down the development of some types of cancer cells in mice and increase the effect of treatments used to eliminate the disease using a dietary supplement found in some fruits.

The researchers conducted a study on mice with pancreatic, lung or cutaneous cancer using mannose of a dietary supplement, a sugar compound found in cranberries and other fruits.

The researchers found that the substance slowed the growth of cancer tumors significantly without showing clear side effects in the mice.

However, cancer patients have been warned against the use of mannose supplementation because of the risk of side effects on humans.

Scientists hope the dietary supplement will soon be tested on humans.

Scientists believe that mangoes affect the ability of cancer cells to use glucose in the body to grow and spread and can be obtained from health stores and is sometimes used to treat urinary tract infections.

"Perfect Balance"
The scientists also analyzed how Manoz influenced cancer treatment drugs and gave him mice that have already received two of the most commonly used drugs in chemotherapy – cisplatin and doxorubicin.

The result was that it helped increase the effect of chemotherapy and thus slowed the growth of tumor tumors and diminished their size. It has also increased the life of some cancer mice.

The various cancerous cells have also been exposed to the manuscript effect in the laboratory, including blood, bone, ovary and intestine cancers.

Some cells responded well, but others did not.

The response of cancer cells mainly depends on the presence of enzyme levels that help break down the mannose supplement.

Professor Kevin Ryan, of the UK's Bateson Research Institute, said his team found that a manganese supplement dose could block enough glucose consumption for cancer cells and then slow down tumor growth in mice, but not affected normal tissues.

Objects need glucose to get energy, but cancerous tumors also use them for feeding, growth and spreading.

Research is still early, but finding this perfect balance means that in the future mannose can be given to cancer patients to promote chemotherapy without harming their health in general, Ryan said.

Additional warning
One of the main advantages of the manual is the cheap price compared to pharmaceuticals produced by pharmaceutical companies.

Professor Ryan said he hoped the human experiments would begin soon.

"Although these findings are very promising for the future of cancer treatments, this research is very early and has not yet been tested on humans," said Martin Ledwick, head of healthcare at the British Cancer Research Center.

He warned that patients should not use manos on their own because there is a real risk of side effects that have not yet been tested.

"It is important to consult a doctor before you change your diet drastically or take new supplements."

Professor Ryan said his team would then analyze why Manoz only worked with a few cancer cells so he could identify the patients who would benefit the most.

The study was published in the journal Nature.

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