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How the bowel speaks with brown fat



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"Surprisingly, we identified secretin as a key factor," says Professor Martin Klingenspor of
Else Kröner-Fresenius-Center for Nutritional Medicine
. Secretin is a known intestinal hormone for a long time.

Up to now, nutritional medicine has assumed that this peptide, as a messenger, essentially fulfills gastrointestinal functions. How to stimulate the secretion of water and bicarbonate in the pancreas as soon as the acidified disease is released from the stomach into the small intestine. In addition, he secrets through the blood as a messenger in the brain to promote satiety. As far as knowledge is concerned until recently.

Secretin breaches energy consumption

The new study revealed with molecular biological studies (transcriptomic sequencing) that secretin receptor gene is also expressed in brown adipose tissue. If we stimulated this receptor in brown-secretin-containing cells, we could see an immediate activation of non-jitter thermogenesis, "explains Prof Klingenspor.

Communication between brown fat and brain

The destruction of thermogenesis is the typical formation of brown heat but not only consumes energy. Research shows that non-agitator thermogenesis is also a prerequisite for brain satiety.

There are three channels of communication from brown to brain:

1. An increase in temperature in the brain,
2. nerve connections from brown to brain;
3. Special greasy brown messages, so-called BATokine.

Professor Klingenspor of EKFZ believes that heat generation is the most plausible possibility at this time: "Thermogenesis in brown fat leads to warming of the blood and a slight increase in temperature in the brain; this activates neurons that signal saturation."

Brown fat plays a key role in satiety

The earlier assumption that secretin acts directly on the brain in certain nerve cells, resulting in satiety and attenuation of hunger, is reviewed by these findings. "Brown fat is interposed, as it were, as a relay station," Prof. Klingenspor sums up the result.

The newly discovered chain of communication between the gut and the brain begins with release of secretin during the meal, by sequential activation of brown lipid thermogenesis and heating in the brain, which increases saturation. For example, food-induced thermogenesis in brown fat consumes energy and makes you rich – both important factors in the therapy and prevention of the almost global epidemic of obesity.

It naturally stimulates secretion production and fills you faster

Secretin would be the right "medicine" in this context? "No," explains Klingenspor. For a chronic stimulation of the pancreas it would be unfavorable. However, he sees a possibility to naturally boost secretin production through certain foods, "the right aperitizer can fill you faster and thus reduce the amount of calories you eat." What nutrients would be considered here are subject to additional studies.

scientific contact:
Professor Martin Klingenspor
Technical University of Munich
Else Kröner-Fresenius-Center for Nutritional Medicine
Department of Molecular Nutrition Medicine
Tel: +49 (8161) 71-2386
E-mail: [email protected]

Original publication:
Yongguo Li *, Katharina Schnabl, Sarah-Madeleine Gabler, Monja Willershäuser, Josefine Reber, Angelina Karlas, Sanna Laurila, Minna Lahesmaa, Mueez & Din, Andrea Bast-Habersbrunner, Kirsi A. Virtanen, Tobias Fromme, Florian Bolze, Libbey S Farrell, Jorge Alsina-Fernandez, Tamer Coskun, Vasilis Ntzihristos, Pirjo Nuutila and Martin Klingenspor: Secretin-activated brown fat meditates prandial thermogenesis to induce cell saturation 11/2018. * equal contribution https://doi.org/10.1016/j.cell.2018.10.016

idw 2018/11

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