Sunday , May 22 2022

The intestinal hormonal layer activates brown adipose tissue


The intestinal hormonal layer activates consumption of energy-consuming brown fat

Researchers have found that secretion of the gut hormone, known for a long time, has an additional feature recently discovered: it activates brown energy-consuming fat tissue, causing satiety.

Brown fat helps reduce weight

Because brown fat cells consume energy, experts say they can be the key to weight loss and important for preventing obesity and diabetes. Only a few weeks ago it was shown that brown fat is activated as much as food and cold. Now, the same team from the Technical University of Munich (TUM) and Finnish colleagues have elucidated the physiological mechanism of this activation.

A new study has shown that intestinal hormone secretion has an additional feature recently discovered: it activates energy-consuming brown fat, causing satiety. New discoveries could be useful in the fight against obesity. (Picture: Kurhan /

Long-known intestinal hormone

"Surprisingly, we identified secretin as a key factor," says study leader Professor Martin Klingenspor of the Kröner-Fresenius Center for Nutritional Medicine (EKFZ) at TUM in a statement.

Secretin is a known intestinal hormone for a long time. Nutritional medicine has so far assumed that this peptide as messenger essentially fulfills gastrointestinal functions.

How to stimulate the secretion of water and bicarbonate in the pancreas as soon as the acidified disease is released from the stomach into the small intestine.

In addition, he secrets through the blood as a messenger in the brain to promote satiety. As far as knowledge is concerned until recently.

Soother in the brain

The new study, published in the journal Cell, has now revealed with molecular biological investigations (transcriptomic sequencing) that secretin receptor gene is also expressed in brown adipose tissue.

"If we stimulated this receptor in brown-secretin-containing fat cells, we could see an immediate activation of non-jitter thermogenesis," explains Prof. Klingenspor.

The destruction of thermogenesis is the typical formation of brown heat but not only consumes energy.

Research shows that non-agitator thermogenesis is also a prerequisite for brain satiety.

Education previously accepted has been revised

As the message says, there are three possible channels of communication from brown to brain:

  1. An increase in temperature in the brain,
  2. Nerve connections from brown fat to brain, or
  3. special messengers of brown fat, the so-called BATokine.

Professor Klingenspor believes that heat generation is the most plausible possible at present:

"Thermogenesis in brown fat leads to warming of the blood and a slight increase in temperature in the brain; this activates neurons that signal saturation."

The earlier assumption that secretin acts directly on the brain in certain nerve cells, resulting in satiety and attenuation of hunger, is reviewed by these findings.

"Brown fat is forbidden, as it was, as a relay station," says Professor Klingenspor.

"The right appertain could fill you up faster"

The newly discovered chain of communication between the gut and the brain begins with release of secretin during the meal, by sequential activation of brown lipid thermogenesis and heating in the brain, which increases saturation.

For example, food-induced thermogenesis in brown fat consumes energy and makes you rich – both important factors in the therapy and prevention of the almost global epidemic of obesity.

So secretina would be the right medicine in this context? "No," explains Klingenspor. For a chronic stimulation of the pancreas it would be unfavorable.

However, the scientist sees a way to naturally stimulate secretion production through certain foods, "the right aperitif can fill you faster and reduce your calorie intake."

What nutrients would be considered here is subject to further studies. (Ad)

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