Wednesday , August 17 2022

The researcher proves the role of microbiom in obesity



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New research presented by Dr. Christoph Thaiss in his award-winning essay for "Science and the SciLifeLab Award for Young Researchers "describe more bacterial metabolites in the human intestine, being modified during obesity.

Microbiome Bacteria - by Kateryna Kon

Kateryna Kon | Shutterstock

While previous studies have correlated body clock disorders with increased blood sugar and obesity, this new research tracks changes in bowel microbial activity for 24 hours, which can change the clock of the host's body.

Earlier research by Thaiss and his team highlights the role of obesity in susceptibility to infections and diets at subsequent weight-related recurrences related to obesity.

The winning essay, titled "Microbiomic Dynamics in Obesity", connects the growing network of taxpayers to obesity.

Changes in body watches, in particular, pose a major threat to people globally who engage in work of irregular change or jet lag. The recurrent increase in post-dieting weight, known as the yo-yo effect, is a common phenomenon in obesity.

Former obese individuals who have successfully lost weight will recover it, which confused obesity researchers.

Thaiss found that obesity caused a certain period of changes in the intestinal microbiota, changes that remained even after the body, the mice in this experiment, returned to a healthy weight.

Increased weight gain associated with the yo-yo effect may be induced in other people by fecal transfer, proving a role for intestinal microbes as an agent that causes obesity.

The next step, according to Thaiss, is the validation of this mouse-based research in human cohorts. This has been done through research into how hyperglycemia leads to the thinning of the intestinal epithelial wall, causing the entry of bacterial molecules into the blood.

In humans, there is a strong correlation between individuals with high blood sugar and levels of microbial products circulating, linking obesity and infectious or inflammatory consequences.

Whether our approach can be used to improve metabolic health in humans is an interesting question we are actively pursuing.

Dr. Christoph Thaiss, winner of the prize

The prize will be presented by SciLifeLab, a Swedish living center, and Science, the magazine appreciated, and is awarded annually to early-stage researchers studying pioneering research.

The prize includes $ 30,000 awarded to the winner by the two supporters, alongside the support of Sweden's largest private funder for research, the Knut Foundation and Alice Wallenberg.

Winners of other categories for this year include Tim Wang for an essay titled "Paring Down to the Essentials," Matthew Savoca for "The Ecology of an Oath Trap" and Ruixue Wan for "A Key Component of Gene Expression." these, together with Thaiss' microbiome obesity dynamics, will be published in Science.

sources:

https://www.nature.com/articles/nature20796

https://www.eurekalert.org/emb_releases/2018-11/aaft-rsn111618.php

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