Immunosuppression prevents early delivery

Naseem News Early childbirth is the leading cause of death and disability in the United States, costing billions of dollars and pain each year.

A report by researchers at the University of Connecticut in Reproductive Science now shows potential treatment that can stop many premature births and give birth to normal.

Hartford obstetrician Christopher Nolde Hospital and immunologist Anthony Villa are intrigued about the role of the immune system in premature birth.

Usually, most pregnancies take about 40 weeks, so a baby born before week 37 may be too small to adjust body temperature and can not breathe, in some cases may have brain bleeds or other organic problems, How it would be the delayed growth and the problems of knowledge and perception.

Only in this country, about 337,000 children were born before birth in 2016. In other mammals, however, early delivery was very rare and usually occurs in case of infection or inflammation.

The researchers have known cytokines – small proteins that alert the body to infections and cause inflammation – in the amniotic fluid of many premature babies. This makes them wonder if the fetus is completely different from his mother, should be attacked by the mother's immune system, but there is something that prevents him from getting pregnant.

"There are a lot of anti-inflammatory mechanisms that prevent immature disinfection of the fetus, so I thought a serious inflammation could break the endurance barrier and begin premature birth and birth," says Villa.

So, Nold and Villa took cells from the female genital channel and the amniotic fluid that surrounded the embryos in the uterus and inserted them into parts of the laboratory bacteria. The result was what the cells expected to produce a lot of cytokines to shout, "There is gas!"

However, cytokines were not originally the type of inflammation that researchers expected, and in contrast, they saw much of the factors that stimulate colonization and granulation (GM-CSF). GM-CSF is a type of cytokine that causes cell growth very quickly to become large follicular cells.

Peat concentrations in pregnant women tend to increase immediately before birth, but it is unclear whether it is directly related to birth or the secondary effect of another procedure.

The discovery by Nold and Villa that cytokine (GM-CSF) is released in response to perceived bacterial infection is odd due to the presence of GM-CSF.

Treatment of pregnant mice with this drug Early birth was significantly reduced in mice exposed to parts of the dangerous bacteria, so if premature birth prevention is simple, it will inevitably change the rules of the game.

Nold and Villa presented a temporary patent on the technique, but researchers must first know whether cytokine (GM-CSF) is what causes the premature birth of women, so Nold collects evidence from some women at the beginning of pregnancy to see if there is anything It can be detected early to determine the cause of premature birth.

Nolde and Villa want to test these cytokine samples (GM-CSF) and see if their high levels at the start of pregnancy are evidence of premature termination of pregnancy.

We hope to do more studies of the immune mechanism in rats and we hope that in the near future we will examine human studies, "said Nold. Hartford Hospital has already awarded a small grant and is now looking for more funding to continue its research .

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• Translation: Kenan Meri
• Checking: RAND EAAM
• Editing: زيد أبو الرب

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